Formulation and evaluation of sustained release paracetamol tablets pdf

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formulation and evaluation of sustained release paracetamol tablets pdf

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The present invention relates to pharmaceutical compositions containing N-acetyl-p-aminophenol, known by the generic names paracetamol, acetaminophen and APAP hereinafter referred to as paracetamol. In particular, the invention relates to a sustained release paracetamol formulation having an advantageous pharmacokinetic profile. Paracetamol is an analgesic and antipyretic agent which is widely used in prescription and non-prescription medicines, often in combination with other biologically active compounds.

Article Information

Objective: The objective of this study was to formulate and evaluate sustained release tablets using cashew gum and cross-linked cashew gum as controlled release polymer. Methods: Full factorial design of 2 3 was employed to optimize the formulation. Tablets were prepared by direct compression and powder properties were evaluated indicating fairly good flow properties. Prepared tablets were evaluated for weight variation, hardness, friability, drug content and for dissolution profile. The optimized formulation obtained from the factorial design was subjected to in vivo studies. Results: In vitro dissolution, swelling and erosion studies were carried out for 12 h in the specified buffer solution. Kinetic analysis of dissolution data showed a good fit in Peppas equation confirming both diffusion and erosion had controlled the drug release.


Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Govedarica and R. Injac and R.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. In the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body.

The analgesic efficacy of single doses of immediate release paracetamol mg and mg, sustained release paracetamol mg, and placebo was evaluated over a 12 h period in 10 healthy volunteers. The efficacy was related to the concurrent plasma concentrations of paracetamol. Experimental pain was induced by brief cutaneous application of argon laser pulses, and the analgesic effect was assessed as change in pricking pain threshold. Both 0. Peak analgesia was reached after 2 h. No difference was found in the analgesic effect of the two dosages.


Paracetamol is an antipyretic and Chlorpheniramine maleate is an antihistamine used to relieve symptoms of hay fever, allergy, and the common cold. Combining both the drugs can be used as pain-relieving and fever in cold and flu conditions. F2 resulted in best wetting time i. No changes in drug release upon storage on different temperature and humidity was estimated in stability studies. The results showed that croscarmellose sodium as the superdisintegrants was ideal.

AJOL and the millions of African and international researchers who rely on our free services are deeply grateful for your contribution. Your donation is guaranteed to directly contribute to Africans sharing their research output with a global readership. Skip to main content Skip to main navigation menu Skip to site footer. Keywords: Sustained release, Paracetamol matrix tablets, Hydroxypropylmethylcellulose, In vitro dissolution tests, Optimization.

US7943170B2 - Sustained release paracetamol containing compositions - Google Patents

Компьютер висел уже почти двадцать часов. Она, разумеется, знала, что были и другие программы, над которыми он работал так долго, программы, создать которые было куда легче, чем нераскрываемый алгоритм. Вирусы.


Стратмор разработал план… и план этот Фонтейн не имел ни малейшего намерения срывать. ГЛАВА 75 Пальцы Стратмора время от времени касались беретты, лежавшей у него на коленях. При мысли о том, что Хейл позволил себе прикоснуться к Сьюзан, кровь закипела в его жилах, но он помнил, что должен сохранять ясную голову, Стратмор с горечью признал, что сам отчасти виноват в случившемся: ведь именно он направил Сьюзан в Третий узел. Однако он умел анализировать свои эмоции и не собирался позволить им отразиться на решении проблемы Цифровой крепости. Он заместитель директора Агентства национальной безопасности, а сегодня все, что он делает, важно, как. Его дыхание стало ровным.

Снова и снова тянется его рука, поблескивает кольцо, деформированные пальцы тычутся в лица склонившихся над ним незнакомцев. Он что-то им говорит. Но что. Дэвид на экране застыл в глубокой задумчивости. - Разница, - бормотал он себе под нос.  - Разница между U235 и U238. Должно быть что-то самое простое.